Below is a list of Clean Rooms manufacturers from Rancho Santa Margarita, California. Clean rooms are enclosures designed to facilitate sensitive research, fabrication and other operations that must take place in the absence of dust, moisture and other airborne contaminants. Clean rooms systems were first developed in response to the needs of the aerospace and microtechnology industries in the early 1960s. As those and other high-tech disciplines like bio-technology and medical research developed, and as products and research subjects became smaller, airborne contaminants became increasingly disruptive. The rigidly controlled environments with which these professionals began to surround their work came to be known as clean rooms.